TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH ANTIOXIDANT SOLUTION: A PILOT STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在囊性纤维化(CF)中，胰腺功能不全和胆酸池减少会导致重要营养物质和饮食成分的吸收不良，从而导致营养状况不佳和氧化应激。特别重要的是脂溶营养素和抗氧化剂的吸收不良，这对正常的免疫和神经功能很重要。此外，这种吸收不良限制了对CF患者有效补充脂类营养素和抗氧化剂，如必需脂肪酸、β-胡萝卜素和维生素E，如果补充水平高于正常饮食，可能会提供好处。一种可以形成胶束状载体的口服液配方可以用来克服CF患者对这些营养物质的吸收不良。这项研究将测试该配方在提高某些营养素和抗氧化剂水平方面的有效性，并评估20名CF患者的氧化应激参数的降低。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In cystic fibrosis (CF), pancreatic insufficiency and a diminished bile acid pool cause malabsorption of important nutrients and dietary components leading to poor nutritional status and oxidative stress. Of particular significance is the malabsorption of fat-soluble nutrients and antioxidants, which are important for normal immune and neurological function. Furthermore this malabsorption limits effective supplementation of CF patients with lipophilic nutrients and antioxidants such as essential fatty acids, beta-carotene and vitamin E, which may provide benefits when supplied at levels higher than those obtained from normal diets. An oral liquid formulation, which can form micelle-like vehicles, can be used to overcome the malabsorption of these nutrients in CF patients. This study will test the efficacy of this formulation in increasing the plasma levels of certain nutrients and antioxidants and evaluate the reduction in oxidative stress parameters in 20 patients with CF.