CYTOKINE LEVELS AND NEUTROPHIL PRIMING IN INFANTS WITH GASTROSCHISIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。胃裂的婴儿通常需要较长的住院时间，包括喂养困难和其他并发症。尽管许多研究都关注了手术类型和修复时间，但许多研究结果都是相互矛盾的。很少有研究关注这些婴儿的炎症标志物，以确定他们是否易患肠功能障碍。患有炎症性肠功能障碍的婴儿容易出现喂养不耐受、坏死性小肠结肠炎，需要进一步的手术干预。在一项初步研究中，我们建议评估腹裂婴儿的脐带血样本，并将其与未腹裂婴儿的对照血液样本进行比较，以确定是否存在促炎细胞因子水平升高或出生时中性粒细胞启动的证据。这表明子宫内存在促炎状态，这可能潜在地识别出易患炎性肠功能障碍的婴儿。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infants with gastroschisis often have a prolonged hospital course involving feeding difficulties as well as other complications. Though many studies have looked at type of surgery and timing of repair, many of their results are conflicting. Few studies have looked at inflammatory markers in these infants to determine if they are predisposed to bowel dysfunction. Infants with inflammatory bowel dysfunction are prone to feeding intolerance, necrotizing enterocolitis, and need for further surgical intervention. In a pilot study, we propose to evaluate cord blood samples from infants with gastroschisis and compare them with blood samples from control infants without gastroschisis to determine if there are elevated levels of pro-inflammatory cytokines or evidence of neutrophil priming at birth. This would suggest that a pro-inflammatory state exists in utero and that could potentially identify infants predisposed to post inflammatory bowel dysfunction.