SIBSHIP LINKAGE STUDY OF NON-MODULATION AND HYPERTENSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究旨在通过对患有高血压的兄弟姐妹进行广泛的表型，然后寻找具有相似表型的兄弟姐妹之间的过度等位基因共享，来确定高血压的候选基因。一种这样的表型是非调制，即对高盐和低盐饮食中注入血管紧张素II的迟钝反应。其他表型可能包括盐敏感性、低肾素高血压、尿皮质醇和对血管紧张素II输注的血压反应。我们还比较了高血压患者和正常血压对照组的中间表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to identify candidate genes for hypertension by extensively phenotyping siblings with hypertension and then looking for excess allele sharing among siblings with similar phenotypes. One such phenotype is non-modulation, a blunted response to infused angiotensin II on high and low salt diets. Other phenotypes may include salt sensitivity, low renin hypertension, urinary cortisol, and blood pressure response to angiotensin II infusion. We are also comparing intermediate phenotypes in hypertensive cases and normotensive controls.