OXIDATIVE STRESS IN AORTIC ANEURYSM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。腹主动脉瘤(AAA)发生在高达9%的65岁人群中。修复AAA的手术技术具有很大的风险，而且还没有特别有效的药物治疗。AAA的高度炎症性质导致(1)ROS的形成增加，以及(2)这些患者保护性抗氧化剂水平的下降。这些发现表明，氧化应激增强，并可能在人类AAA的发病机制中发挥作用。虽然我们的长期假设是，有效的抗氧化剂治疗可以减缓AAA患者的AAA生长及其后果(即破裂)，但该试点项目的目的是确定一种临床有效的抗氧化剂方案，以减少AAA患者的氧化应激。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abdominal aortic aneurysms (AAA) occur in up to 9% of persons >65 years of age. Surgical techniques to repair AAA carry significant risks, and there is no particularly effective medical therapy. The highly inflammatory nature of AAA leads to (1) an increase in the formation of ROS, and (2) a decrease in the levels of protective antioxidants in these patients. These findings suggest that oxidative stress is enhanced and may play a role in the pathogenesis of AAA in humans. While our long-term hypothesis is that effective antioxidant therapy can attenuate AAA growth and its consequences (i.e., rupture) in patients with AAA, the purpose of this pilot project is to identify a clinically effective antioxidant regimen that reduces oxidative stress in AAA patients.