BACTEREMIA IN SUBJECTS WITH LIVER DISEASE COMPARED TO OTHER CHRONIC ILLNESS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。已有研究表明，脓毒症患者肝功能衰竭与预后不良有关。肝脏通过网状内皮系统参与细菌清除。此外，库普弗细胞是全身性感染过程中细胞因子的重要来源。我们的动物数据表明，小鼠肺炎和败血症模型的肝损伤程度（表现为ALT水平）与全身性菌血症水平相关。此外，随着全身性菌血症水平的增加，死亡率也会增加。因此，我们假设肝脏疾病与细菌清除率降低有关，从而导致菌血症增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It has been shown that liver failure is associated with poor prognosis in patients with sepsis. The liver participates in bacterial clearance via the reticular-endothelial system. In addition, Kupffer cells are an important source of cytokines during systemic infection. Our animal data suggests that the degree of liver injury (manifest as level of ALT) in a murine model of pneumonia and sepsis correlates with the level of systemic bacteremia. In addition, as the levels of systemic bacteremia increase, the mortality increases as well. Therefore, we hypothesize that liver disease is associated with decreased bacterial clearance which results in increased bacteremia.