EDIC (EPIDEMIOLOGY OF DIABETES INTERVENTIONS & COMPLICATIONS)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该方案主要是1型糖尿病及其并发症的流行病学研究，特别强调大血管疾病。EDIC被设计为糖尿病控制和并发症试验（DCCT）参与者的长期随访。DCCT于1994年完成，是一项著名的前瞻性随机试验，共有1441名受试者随机分为强化血糖控制组和常规血糖控制组。结果为血糖控制对预防微血管和神经系统并发症的益处提供了令人信服的证据。现在，EDIC为这一大规模受试者的持续前瞻性随访提供了机会，从而为糖尿病并发症的发生、发病机制、危险因素和治疗提供了新的数据。EDIC还利用了基于先前参与DCCT的研究人群的先前意向治疗分析。此外，EDIC促进了1型糖尿病大血管疾病的研究，这是DCCT在5-9岁相对年轻的受试者（入组时为13-39岁）中无法充分解决的问题。EDIC还纳入了涉及参与者家庭成员的遗传成分，以便更多地了解基因对1型糖尿病长期并发症的发生和进展的贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is primarily an epidemiological study of type 1 diabetes and its complications with particular emphasis on macrovascular disease. The EDIC is designed as a long-term follow-up of participants in the Diabetes Control and Complications Trial (DCCT). The DCCT, which was completed in 1994, was a well known prospective randomized trial of 1,441 subjects randomized to intense versus conventional glycemic control. The results provided compelling evidence of the benefit of glycemic control towards preventing microvascular and neurological complications. The EDIC now offers an opportunity for continued prospective follow-up of this large group of subjects, thus promising new data on the occurrence, pathogenesis, risk factors and treatments of diabetic complications. The EDIC also takes advantage of prior intention-to-treat analysis based on previous involvement of the study population in the DCCT. In addition, the EDIC facilitates the study of macrovascular disease in type 1 diabetes, an issue that the DCCT could not adequately address over the 5-9 year participation of the relatively young subjects (13-39 years old at enrollment in the DCCT). The EDIC also incorporates a genetic component involving family members of participants in order to learn more about the contribution of genes to the development and progression of the long-term complications of type 1 diabetes.