THE EARLY EXTERNAL CEPHALIC VERSION 2 TRIAL (EEVC2)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是证实一项初步研究的结果，该研究表明，早期体外头位(ECV)后出生时非头位(臀位)的发生率降低了9.5%，并确定早期开始ECV(34-35周对37周)将在不增加早产儿或严重胎儿并发症的情况下降低剖宫产率(CS)。所有足月妊娠的3%到4%将是臀位。研究表明，臀位分娩最安全的方法是CS。CS因孕产妇死亡率和发病率而变得复杂。从怀孕37周开始的一种被称为头外翻转(ECV)的技术可以降低CS的发生率，但在美国和欧洲的经验中，未分娩的妇女的成功率一直是30%。这项研究旨在评估34-35周开始早期ECV的成功率，并在随机对照试验设计中与妊娠37周延迟ECV的成功率(护理标准)进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this study are to confirm findings of a pilot study that demonstrated a 9.5% reduction in the rate of non-cephalic (breech) presentation at birth following early external cephalic version (ECV) and to determine that beginning ECV early (34-35 vs 37 weeks gestation) will decrease the rate of Cesarean section (CS) without an increase in the rate of pre-term births or serious fetal complications. Three to four percent of all term pregnancies will be breech. Research has indicated that the safest method of delivery of breech presentation is CS. CS is complicated by maternal mortality and morbidity. A technique called external cephalic version (ECV) beginning at 37 weeks gestation can lower the CS rate but the success rate has been 30% for nulliparous women in American and European experience. This research study seeks to evaluate the success rate of early ECV beginning at 34-35 weeks and compare in a randomized controlled trial design to that of delayed ECV at 37 weeks gestation (standard of care).