BODY COMPOSITION AND FUNCTIONAL ANALYSIS OF KNEE OSTEOARTHRITIS TO OBESITY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。膝关节骨关节炎（OA）是残疾的常见原因，肥胖是一个强大的危险因素。肥胖和髋关节骨性关节炎之间没有关联，女性BMI和膝关节骨性关节炎之间的相关性比男性更强，这表明体重增加本身可能不是膝关节骨性关节炎风险升高的原因。肥胖和膝关节OA之间关系的机制尚未确定，但已经提出了相对的股四头肌无力和内侧室负荷增加。先前的研究表明，肥胖的人比非肥胖的人拥有更大的绝对股四头肌力量。本研究将探讨是否存在力量：下肢瘦体质量（LBM）关系的差异在正常体重和肥胖的受试者有和没有膝关节OA。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA) of the knee is a common cause of disability, and obesity is a strong risk factor. There has been no association between obesity and hip OA and the correlation between BMI and knee OA has been stronger in women than men, suggesting that increased weight alone may not account for elevated knee OA risk. The mechanism for the relationship between obesity and knee OA has not been established, but both relative quadriceps weakness and increased medial compartment loading have been proposed. Prior studies have shown that obese subjects have greater absolute quadriceps strength than non-obese subjects. This study will examine whether there are differences in the strength:lower limb lean body mass (LBM) relationship between normal weight and obese subjects with and without knee OA.