COUPLING OF D-CHIRO-INOSITOL TO INSULIN IN NORMAL AND PCOS WOMEN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是在正常妇女和多囊卵巢综合征(PCOS)妇女中测试胰岛素和一种名为D-甲酰肌醇的分子之间的关系。作为一项试验性研究，其具体目的是确定DCI-IPG生物活性是否与正常女性糖耐量试验中的胰岛素分泌密切相关，是否与多囊卵巢综合征患者糖耐量试验中的胰岛素分泌无关，选择性抑制胰腺胰岛素分泌是否影响DCI-IPG生物活性，以及使用长时间稳态正血糖胰岛素钳分次输注胰岛素是否对既往接受二氮卓治疗的女性有生物活性影响。正常女性和体重指数匹配的多囊卵巢综合征女性将被比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to test the relationship between insulin and a molecule called D-chiro-inositol in normal women and women with polycystic ovary syndrome (PCOS). As a pilot study the specific aims are to determine whether DCI-IPG bioactivity closely correlates with insulin secretion during a glucose tolerance test in normal women, fails to correlate with insulin secretion in women with PCOS during a glucose tolerance test, whether selective inhibition of pancreatic insulin secretion effects DCI-IPG bioactivity, whether stepwise insulin infusion using long duration steady state euglycemic insulin clamp has a bioactivity effect on women previously treated with diazoxide. Normal women and BMI matched women with PCOS will be compared.