INTERACTION OF HIV MEDICATIONS WITH OPIATE THERAPY MEDICATIONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的目的是澄清长期使用的阿片类药物之间是否存在显著的药物相互作用，阿片类药物（通常是海洛因）成瘾的维持治疗和经常处方的抗逆转录病毒药物。 药物滥用者中艾滋病病例的比例日益增加，以及在这一人群中难以获得和坚持艾滋病毒治疗，从临床和公共卫生的角度来看，都令人极为关切。迄今为止，所有艾滋病毒治疗药物都是在临床上开发的，并在艾滋病毒疾病患者中进行了测试，但没有阿片类药物依赖。鉴于艾滋病毒在阿片类药物依赖患者中的迅速传播以及病毒通过性接触和注射使用者共用针头传播的可能性，强调了了解如何最好地治疗这一群体中的阿片类药物依赖和艾滋病毒疾病的重要性。特别重要的是，以评估对艾滋病毒治疗的替代阿片激动剂用于阿片类药物依赖的药物治疗处置的影响。 将从药物滥用治疗诊所招募受试者。受试者将接受入组筛选，入组后，将作为门诊患者和住院患者接受给药、评估和抽血。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to clarify the presence or absence of significant drug interactions between opioids used in long term, maintenance treatment of opiate (usually heroin) addiction and frequently prescribed antiretroviral medications. The increasing proportion of AIDS cases in substance abusers and difficulties in providing access and adherence to HIV therapeutics in this population are of great concern from both clinical and public health perspectives. All HIV therapeutics to date have been clinically developed and tested in patients with HIV disease, but without opioid dependence. Given the rapid spread of HIV in opioid dependent patients and the potential for spread of the virus via sexual contact and use of shared needles in injection users, the importance of understanding how best to treat both opioid dependence and HIV disease in this group is underscored. It is especially important to evaluate the effect on the disposition of HIV therapeutics of alternative opiate agonists used for the pharmacotherapy of opiate dependence. Subjects will be recruited from the substance abuse treatment clinic. Subjects will be screened for enrollment and upon enrollment, will be seen both as outpatients and as inpatients for drug administration, assessments, and blood draws.