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Role of Buprenorphine in Improving Clinical Care in Opioid Addiction and HIV

丁丙诺啡在改善阿片类药物成瘾和艾滋病毒临床护理中的作用

基本信息

批准号：
8049630
负责人：
Elinore F. McCance-Katz
金额：
$ 18.56万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-15 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8049630
关键词：
AIDS/HIV problem Abscess Age Agonist Analgesics Anesthesiology Anti-Retroviral Agents Atazanavir Bacterial Endocarditis Baltimore Behavior Therapy Boston Buprenorphine Caring Cellulitis Cities Clinical Clinical Investigator Clinical Pharmacology Clinical Research Clinical Trials Clinical Trials Network Combination Medication Communicable Diseases Communities Data Analyses Data Reporting Didanosine Disease Doctor of Medicine Doctor of Philosophy Drug Interactions Drug abuse Drug usage Drug user Educational Activities Epidemic Epidemiology Ethics Faculty Funding Future Goals Grant HIV Health Health Services Accessibility Healthcare Hepatitis B Hepatitis C Heroin Heroin Abuse Heroin Dependence Human Hydrocodone Incidence Individual Injection of therapeutic agent K-Series Research Career Programs Laboratories Laboratory Study Lead Life Los Angeles Manuscripts Medical Medical Students Medicine Mentors Methadone Methadyl Acetate Midcareer Investigator Award in Patient-Oriented Research Monitor Naloxone National Institute of Drug Abuse Nevirapine New York Opiate Addiction Opiates Opioid Oxycodone Participant Patients Pattern Pediatrics Pharmaceutical Preparations Pharmacotherapy Physicians Physicians&apos Offices Population Postdoctoral Fellow Preparation Prevalence Psychiatry Public Health Qualifying Reporting Research Research Design Research Methodology Research Personnel Research Project Grants Research Proposals Research Subjects Ritonavir Role Route Sampling San Francisco Sepsis Site Specific qualifier value Students Substance Use Disorder Surveys Tenofovir Therapeutic Time Toxic effect Training United States Universities addiction age group antiretroviral therapy base career development chronic pain clinical care drug of abuse fosamprenavir high risk human subject protection improved interest medical schools methadone maintenance nonmedical use novel opioid abuse patient oriented research prescription opioid prescription opioid abuse success

项目摘要

DESCRIPTION (provided by applicant): This Midcareer Investigator Award in Patient Oriented Research (K24) will provide the candidate with the opportunity to continue her own career development, to continue to mentor beginning clinical investigators, resident physicians, and students in research methods, to disseminate new research findings in addiction medicine, specifically in the treatment of opioid dependence and comorbid opioid dependence and HIV disease, and to continue research in defining drug interactions between buprenorphine and antiretroviral medications as well as to undertake clinical trials to further illuminate how to effectively treat prescription opioid addiction. The overarching goal of this K award will be to enhance the clinical care of opioid-addicted patients through the successful completion of currently funded NIDA studies and to use the clinical research setting to train young investigators in addiction medicine and in the undertaking of well-designed research that will ultimately lead to their success as independent investigators. The Specific Aims of the research proposal include completion of the Pi's funded NIDA RO1 research project to identify drug interactions and their clinical importance between buprenorphine, a newer opioid partial agonist available by prescription from qualified physicians and HIV therapeutics and a clinical trial funded through the NIDA Clinical Trials Network that will examine buprenorphine/naloxone treatment plus medical management or enhanced medical management for treatment of patients addicted to prescription opioids. The mentoring plan will focus on training junior faculty in psychiatry, medicine, anesthesiology, and pediatrics, psychiatry residents, postdoctoral fellows in addiction psychiatry, medical students, and graduate and undergraduate students to conduct patient-oriented research in addiction medicine. The training will focus on clinical research methods including human laboratory-based paradigms and clinical trials, data analysis, manuscript and grant preparation, presentation of research findings, conduct of ethical research and human subjects protections. Mentoring will occur through participation in the Pi's funded research projects and educational activities available within Addiction Psychiatry, the School of Medicine, and VCU. Over the next 5 years the candidate seeks to devote full time effort to research and mentoring with the goal of advancing patient oriented research in opioid dependence and helping to increase the number of new investigators in the field.

描述(申请人提供)：这个以患者为中心的职业生涯中期研究人员奖(K24)将为候选人提供机会继续她自己的职业发展，继续指导初级临床研究人员、住院医生和学生的研究方法，传播成瘾医学方面的新研究成果，特别是在阿片依赖和共病阿片依赖与艾滋病毒疾病的治疗方面，并继续研究丁丙诺啡和抗逆转录病毒药物之间的药物相互作用，以及进行临床试验以进一步阐明如何有效治疗处方阿片成瘾。K奖的首要目标将是通过成功完成目前资助的NIDA研究来加强对阿片成瘾患者的临床护理，并利用临床研究环境培训年轻研究人员成瘾药物和进行精心设计的研究，最终使他们成为成功的独立研究人员。研究建议的具体目标包括完成PI资助的NIDA RO1研究项目，以确定丁丙诺啡之间的药物相互作用及其临床重要性，丁丙诺啡是一种较新的阿片部分激动剂，可从合格医生和艾滋病毒疗法的处方中获得，以及由NIDA临床试验网络资助的一项临床试验，该试验将检查丁丙诺啡/纳洛酮治疗与治疗处方阿片成瘾患者的医疗管理或加强医疗管理。该辅导计划将重点培训精神病学、医学、麻醉学和儿科学方面的初级教员、精神病学住院医师、成瘾精神病学博士后研究员、医学生以及研究生和本科生，以开展以患者为导向的成瘾医学研究。培训将侧重于临床研究方法，包括以人体实验室为基础的范例和临床试验、数据分析、手稿和赠款准备、研究结果的陈述、伦理研究的开展和人类受试者的保护。辅导将通过参与PI资助的研究项目和成瘾精神病学、医学院和VCU提供的教育活动来进行。在接下来的5年里，候选人寻求将全部时间投入到研究和指导上，目标是推进阿片类药物依赖的以患者为导向的研究，并帮助增加该领域的新调查人员的数量。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Untreated HIV infection is associated with higher blood alcohol levels.

未经治疗的艾滋病毒感染与较高的血液酒精浓度有关。

DOI：
10.1097/qai.0b013e318256625f
发表时间：
2012
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
0
作者：
McCance-Katz,ElinoreF;Lum,PaulaJ;Beatty,George;Gruber,ValerieA;Peters,Marion;Rainey,PetrieM
通讯作者：
Rainey,PetrieM

Indicators of Buprenorphine and Methadone Use and Abuse: What Do We Know?