COMPENSATORY CHANGES IN RENAL SENESCENCE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的目的是比较单肾切除术（手术切除一个肾脏）后老年人与年轻人的肾功能。我们计划比较年轻和老年肾移植供体的肾功能。此外，我们计划研究年轻和老年患者谁经历了单肾切除术的结果，在切除的肾脏肾上腺瘤。众所周知，人类可以通过剩余肾脏的代偿性肥大来适应一个肾脏的丧失，因为它适应恢复肾功能。过去的研究人员认为，肾功能随着年龄的增长而下降，但最近的文献表明，并非所有人都受到这种下降的影响。此外，尚不清楚在单侧肾切除术后，老年肾供体是否可以在剩余的肾中经历与年轻肾供体相同程度的补偿：换句话说，在切除另一个肾后，老年肾能否像年轻肾一样进行补偿。很少有试验报道了这一点，在这些试验中，有相互矛盾的结果。 我们希望调查健康活体供肾者在肾脏捐献前后的肾功能（胰岛素清除率），目的是比较年轻供肾者与老年供肾者的结果。由于老年（60岁以上）肾脏供体的数量较少，我们将纳入因肾功能亢进而接受单肾切除术的受试者，并在该人群中研究老年和年轻患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to compare the kidney function in the aged versus the young, following uninephrectomy (surgical removal of one kidney). We plan to compare kidney function in young and aged kidney transplant donors. In addition, we plan to study young and aged patients who have undergone uninephrectomy as a result of hypernephroma in the removed kidney. It is well known that humans can adapt to the loss of one kidney, through compensatory hypertrophy of the remaining kidney as it adapts to restore renal function. Past investigators have suggested that kidney function declines with age, but recent literature suggests that not all humans are subject to this decline. Furthermore, it is unknown whether the aged kidney donor can undergo compensation, in the remaining kidney, to the same degree as the young kidney donor after uninephrectomy: in other words, can the aged kidney compensate as well as the young kidney, following removal of the other kidney. Very few trials have reported on this, and amongst these trials, there are contradictory findings. We wish to investigate kidney function (insulin clearance) before and after kidney donation in healthy living donors, with the purpose of comparing the findings in the young donors versus the old donors. Because the number of aged (60+ yrs) kidney donors is small, we will include subjects who have undergone uninephrectomy due to hypernephroma, and study old and younger patients in this population as well.