INFLUENCE OF DIFFERENT INTENSITIES OF RESISTANCE TRAINING ON GLUCOSE UPTAKE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。几项研究表明，急性运动和运动训练可以对健康和葡萄糖不耐受受试者的胰岛素敏感性和葡萄糖摄取产生积极影响。有氧耐力训练一直是大多数研究的焦点，尽管最近对阻力训练及其对葡萄糖摄取的影响的兴趣有所增加。运动期间葡萄糖的利用取决于运动的强度和持续时间。 到目前为止，很少有人知道不同的运动强度，在一个单一的会议阻力训练相同的工作量，可能对葡萄糖摄取的影响。以前的工作检查运动强度对葡萄糖摄取的影响没有利用相等工作量的阻力训练课程，因此难以确定提高葡萄糖摄取的阻力训练强度的最佳水平。本研究调查的目的是检查葡萄糖摄取对高强度阻力训练和低强度阻力训练的反应，其中两次训练的训练量相等。将在高胰岛素正葡萄糖钳夹试验过程中监测葡萄糖摄入。 每个人都将在没有运动的情况下参加钳夹程序，以进行对照测量，并在高强度和低强度训练课程完成后的早晨参加钳夹程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several investigations have shown that acute exercise and exercise training can have positive effects on insulin sensitivity and glucose uptake in both healthy and glucose-intolerant subjects. Aerobic endurance training has been the focus of most research, although interest in resistance training and its effects on glucose uptake has increased recently. Utilization of glucose during exercise is dependent upon the intensity and duration of the exercise session. To date, little is known about the effects that different exercise intensities, of equal workloads during a single session of resistance training, may have on glucose uptake. Previous work examining the effects of exercise intensity on glucose uptake has not utilized resistance training sessions of equal work volumes, thus making it difficult to determine an optimum level of resistance training intensity that enhances glucose uptake. The purpose of this research investigation will be to examine glucose uptake in response to a session of high-intensity resistance training and a session of low-intensity resistance training, where both training sessions are of equal training volume. Glucose uptake will be monitored during a hyperinsulinemic euglycemic clamp test procedure. Each individual will participate in a clamp procedure after no exercise for a control measurement, and the morning after the completion of the high- and low-intensity training sessions.