ROLE OF COMPLEMENT RECEPTOR 2 IN SYSTEMIC LUPUS ERYTHEMATOSUS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。补体受体2是抗体产生细胞上的一种蛋白质，被认为在狼疮中起着重要作用。我们已经证明，在狼疮的动物模型中，这种蛋白的基因是异常的，这为它导致狼疮提供了强有力的证据。这种受体在狼疮患者的血细胞中也存在于较低水平。在这项研究中，我们想要确定受体的这种变化是否与狼疮患者的病情有关。我们将每隔3个月观察狼疮患者血细胞上这种受体的数量，为期一年，看看当他们的狼疮更活跃时，这种受体的数量是否会下降。我们还将努力找出为什么水平会下降，因为这可能有助于我们了解狼疮的原因，并找到更好的治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Complement receptor 2 is a protein on antibody-producing cells believed to be important in lupus. We have shown that the gene for this protein is abnormal in an animal model of lupus, providing strong proof that it causes lupus. This receptor is also present at lower levels on the blood cells of people with lupus. In this study, we want to determine whether this change in the receptor is related to how sick a person with lupus is. We will look at the amount of this receptor on the blood cells of people with lupus at 3 month intervals for one year to see if the amount goes down when their lupus is more active. We will also try to sort out why the levels go down since this may help us understand what causes lupus and find better treatments.