NEUROMUSCULAR CONDITIONING THERAPY FOR DYSSYNERGIC DEFECATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项多学科的提案将调查标准和创新的替代疗法对因排便功能障碍而导致的便秘患者的疗效。便秘影响着至少400万美国人，主要是妇女和老年人。它的特点很差，没有得到充分的治疗。至少50%的慢性便秘患者表现出排便不协调或协同失调。在这些患者中，生物反馈治疗可能会改善症状。这项提议涉及三个大目标。第一项是确定生物反馈疗法对排便障碍的治疗是否有效，第二项是调查家庭训练的效果，第三项是调查心理社会功能和生活质量，以及治疗对这些参数的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This multidisciplinary proposal will investigate the efficacy of both standard and innovative, alternative treatments for patients with constipation due to dyssynergic defecation. Constipation affects at least four million Americans, predominantly women and the elderly. It is poorly characterized and inadequately treated. At least 50% of patients with chronic constipation exhibit uncoordinated or dyssynergic defecation. In these patients, biofeedback therapy may improve symptoms. This proposal addresses three broad objectives. The first is to determine if biofeedback therapy is effective in the management of dyssynergic defecation, the second is to investigate the efficacy of home-training and the third is to investigate the psychosocial function and quality of life and the impact of treatment on these parameters.