ATKINS DIET IN EPILEPSY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。生酮饮食是一种高事实、低蛋白和低碳水化合物的饮食，通过在体内产生酮症状态来模拟饥饿，已被证明可以减少癫痫儿童的癫痫发作频率。最近，有关这种饮食对成年人可能有用的数据已经公布。然而，饮食非常严格，不容易利用。阿特金斯饮食是一种高脂肪、高蛋白、低碳水化合物的饮食，被广泛用于减肥。在这种饮食的诱导阶段（当碳水化合物摄入量<20 g/天），可以诱导酮症。我们的假设是，阿特金斯饮食诱导的酮症可以有效地治疗癫痫，其方式与生酮饮食相似，而没有严重的限制。我们有一个现行方案（03-07-24-01）来评估儿童的阿特金斯饮食。本研究仍处于入组阶段。然而，阿特金斯饮食作为癫痫发作的治疗方法可能对成年人产生最大的影响。这是因为成年人传统上不鼓励生酮饮食，因为担心严重的限制性，体重减轻和高脂血症。因此，我们提出了一项前瞻性研究，以确定阿特金斯饮食是否有效地减少癫痫发作，改善生活质量，创造酮症，并在成人顽固性癫痫发作的耐受性良好。本方案已获得JHH IRB批准（04-02-27-08）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ketogenic diet, a high fact, low protein and low carbohydrate diet which mimics starvation by creating a state of ketosis in the body has been shown to reduce the frequency of seizures in children with epilepsy. More recently, data has become available regarding the possible utility of this diet in adults. However, the diet is very strict and is not easy to utilize. The Atkins Diet is a high fat, high protein, low carbohydrate diet that is being utilized extensively for weight loss. During the induction phase of this diet (when carbohydrate intake is <20g/day), ketosis can be induced. Our hypothesis is that the ketosis induced by the Atkins Diet could be effective in treating epilepsy in a similar manner to the ketogenic diet without the severe restrictiveness. We have a current protocol (03-07-24-01) to evaluate the Atkins Diet in children. This study is still in the enrollment phase. However, the Atkins Diet as a treatment for seizures may have its greatest impact in adults. This is because adults have traditionally been discouraged from the ketogenic diet due to concerns about severe restrictiveness, weight loss and hyperlipidemia. Therefore, we propose a prospective study to determine whether the Atkins Diet is efficacious for reducing seizures, improves quality of life, creates ketosis, and is well tolerated in adults with intractable seizures. This protocol has been approved by the JHH IRB (04-02-27-08).