BOLD FMRI IN MR RESEARCH TO MAP LEARNING HISTORIES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本提案的总体目标是评估视觉任务作为理解健康和疾病衰老生理学的模型。我们将比较健康受试者与接受雌激素替代治疗（ERT）的受试者以及患有帕金森病（PD）和黄斑变性（MD）的老年受试者的结果。我们评估的视觉系统，以获得详细了解这个输入-输出感觉运动回路，因为在这个系统中的缺陷可能会导致显着的发病率在老年人从福尔斯和机动车事故。此外，我们正在研究的神经退行性疾病在视觉和运动系统中有表现。我们希望获得这些主题的NIH计划项目资助的试点数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposal is to evaluate a visuomotor task as a model for understanding the physiology of aging in health and sickness. We will compare the findings from healthy subjects with those undergoing estrogen replacement therapy (ERT) and older subjects with Parkinson's disease (PD) and macular degeneration (MD). We evaluate the visuomotor system to gain a detailed understanding of this input-output sensorimotor loop and because deficits in this system can lead to significant morbidity in the elderly from falls and motor vehicle accidents. Also, the neuro-degenerative disorders we are studying have manifestations in the visual and motor systems. We wish to obtain pilot data for an NIH program project grant on these subjects.