MEAL-RELATED ENDOCRINE RESPONSES IN ANOREXIA NERVOSA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。神经性厌食症(AN)是精神疾病中死亡率最高的一种高度病态疾病。影响1-2%的女性人口和0.1-0.2%的男性人口，其特征是拒绝保持最低可接受的体重，对体重增加有强烈的恐惧，以及扭曲的身体形象。神经性厌食症引起的长期营养不良与内分泌功能的改变有关。对食物摄入量的长期和短期反应都有记录，但这些变化的性质迄今尚未得到很好的描述。这项研究将测量饥饿、半喂养和恢复状态下神经性厌食症患者的膳食诱导内分泌反应。饥饿感、饱腹感、恶心和焦虑的感觉也将在每个测试点的测试餐之前、期间和之后进行测量。这些测量将有助于表征饥饿对膳食诱导的激素变化的影响，并评估这些变化是否对治疗起反应或是神经性厌食症的后果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa (AN) is a highly morbid condition with the highest mortality rate among psychiatric disorders. Affecting 1-2% of the female population and 0.1-0.2% of the male population, it is characterized by refusal to maintain a minimally accepted body weight, intense fear of weight gain, and distorted body image. Prolonged malnutrition due to anorexia nervosa has been associated with alterations in endocrine function. Both long- and short-term responses to food intake have been documented, but the nature of these changes has not been well characterized to date. This study will measure meal-induced endocrine responses in persons with anorexia nervosa in the starved, semi-fed, and recovered state. Perception of hunger, satiety, nausea, and anxiety will also be measured before, during and after a test meal at each testing point. These measurements will serve to characterize the effects of starvation on meal-induced hormone changes and to assess whether these changes respond to treatment or are consequences of anorexia nervosa.