THE VALIDITY OF DUCTAL LAVAGE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。乳腺导管灌洗（用微导管在乳头导管内插管并用生理盐水灌洗以收集乳腺上皮导管细胞）已成为一种潜在的乳腺癌检测技术。该方法的有效性尚不清楚，尽管该方法作为乳房x线摄影的辅助手段用于早期乳腺癌检测。具体的研究问题是：导管灌洗诊断女性不典型增生和/或乳腺癌的敏感性和特异性如何？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast ductal lavage (nipple ducts are cannulated with a microcather and lavaged with normal saline to collect breast epithelial ductal cells) has emerged as a potential technique for breast cancer detection. The validity of the procedure is unknown although the procedure is being marketed as an adjuvant to mammography for early breast cancer detection. The specific research question is: What's the sensitivity and specificity of ductal lavage for the diagnosis of atypical hyperplasia and/or breast cancer among women?