GENETICS OF PEDIATRIC-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是确定特定基因是否与系统性红斑狼疮（SLE）的易感性相关。据推测，几个基因将被发现与SLE的表型。具体的目的是筛选大量的系统性红斑狼疮儿童及其家庭，并进行遗传分析，以确定相关的表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if specific genes are associated with susceptibility to systemic lupus erythematosus (SLE). It is hypothesized that several genes will be found which are associated with the phenotype of SLE. The specific aim is to screen a large population of children with systemic lupus erythematosus and their families and perform genetic analyses to identify associated phenotypes.