SPIRITUAL WELL-BEING AND DEPRESSION IN HEART FAILURE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在住院期间发现的心力衰竭抑郁与健康状况差、生活质量下降、再住院率和死亡率高有关。确定与抑郁症相关的可补救因素可能为干预措施提供目标，以减少这些不利后果。之前的研究已经证明，癌症患者的精神健康与较低的抑郁率之间存在联系。广义地说，灵性可以被定义为人们理解生活中的终极意义和价值的方式。这项研究的主要目的是测试在老年晚期心力衰竭患者中评估精神健康的可行性，并确定精神健康水平较低是否与抑郁有关。65岁以上患有晚期心力衰竭的患者数量正在迅速增长。预防和治疗抑郁症的新方法是必要的。精神可能是晚期心力衰竭患者抑郁负担沉重的重要因素。改善精神健康是预防或治疗抑郁症的一种潜在干预措施。实现这一长期目标的第一步是更好地了解这一人群中灵性与抑郁症之间的关系。我们将使用横断面设计来评估60名65岁以上患有纽约心脏协会(NYHA)2、3或4级心力衰竭或D期心力衰竭的门诊患者。我们将使用慢性病治疗功能评估-精神幸福量表(FAIT-SB)来衡量精神健康，这是一种已经在大样本严重疾病患者中得到开发和验证的测量方法。在部分患者中进行的半结构化访谈将通过探索参与者对精神健康和情绪之间关系的看法来补充调查。这些采访还将调查医疗保健专业人员如何解决未得到满足的精神需求。这项初步研究将有助于我们理解精神与晚期心力衰竭患者抑郁的关系，并可能建议哪些方面的精神值得进一步研究，作为在这一人群中减少抑郁的潜在目标。此外，该项目将提供有关解决晚期心力衰竭患者未得到满足的精神需求的潜力的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Depression detected during hospitalization for heart failure is associated with poor health status, decreased quality of life, higher readmission rates, and higher mortality. Identifying remediable factors associated with depression may provide targets for interventions to reduce these adverse outcomes. Previous research has demonstrated a link between spiritual well-being and lower rates of depression in patients with cancer. Broadly, spirituality may be defined as the way in which people understand ultimate meaning and value in their lives. The primary objectives of this study are to test the feasibility of assessing spiritual well-being in a sample of elderly patients with advanced heart failure and to determine if lower levels of spiritual well-being are associated with depression. The number of patients over age 65 with advanced heart failure is growing rapidly. Novel approaches to prevent and treat depression are needed. Spirituality may be an important factor in the large burden of depression in patients with advanced heart failure. Improving spiritual well-being represents a potential intervention to prevent or treat depression. The first step in achieving this long term goal is to better understand the relationship between spirituality and depression in this population. We will use a cross-sectional design to evaluate 60 outpatients over age 65 with Class 2, 3, or 4 New York Heart Association (NYHA) heart failure or Stage D heart failure. We will measure spiritual well-being with the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sb), a measure that has been developed and validated in a large sample of patients with serious medical illness. Semi-structured interviews in a subset of patients will complement surveys by exploring participants' views about the relationship between spiritual well-being and mood. These interviews will also investigate how healthcare professionals might address unmet spiritual needs. This preliminary study will contribute to our understanding of the relationship of spirituality to depression in patients with advanced heart failure and may suggest what aspects of spirituality merit further study as potential targets for reducing depression in this population. Furthermore, this project will provide information about the potential for addressing unmet spiritual needs in patients with advanced heart failure.