ABSORPTION OF IRON PROTOPORPHYRIN AND FERROUS SULFATE IN TODDLERS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。缺铁性贫血在美国的幼儿中很常见。几十年来，人们一直在断奶食品中添加铁，试图解决和治疗这种情况。这种强化的效果一直受到质疑，因为用具有高生物利用度的铁源来强化米粥特别困难。虽然已经发现干牛血红蛋白形式的铁比无机铁具有更高的生物利用度，但可接受性和变色问题阻碍了其作为强化剂的常规使用。原卟啉铁，即血红蛋白中含铁的部分，可以从动物源中分离出来，也可以用化学方法制造。我们将研究化学合成的原卟啉铁与硫酸亚铁的吸收，硫酸亚铁是一种非血红素铁来源，通常用于强化断奶食品，经常被儿科医生用于治疗缺铁性贫血。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Iron deficiency anemia is common in toddlers of the United States. Weaning foods such as rice cereal have been fortified with iron for decades in an attempt to address and treat this condition. The efficacy of such fortification has been doubted as it is particularly difficult to fortify rice cereal with sources of iron that have high bioavailability. While iron in the form of dried bovine hemoglobin has been found to have higher bioavailability than inorganic iron, issues of acceptability and discoloration have impeded its routine use as a fortificant. Iron protoporphyrin, the iron- containing portion of hemoglobin, can be isolated from animal sources or manufactured chemically. We will examine the absorption of chemically manufactured iron protoporphyrin with the absorption of ferrous sulfate, a non-heme iron source commonly used to fortify weaning foods and frequently prescribed by pediatricians for the treatment of iron deficiency anemia.