PILOT STUDY IN PHYSIOLOGIC QUANTIFICATION OF INSULIN - RELATED TRAITS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。提案的目的是在20名受试者中进行胰岛素抑制试验（IST），以获得经验并培训我们的员工。IST是一项生理学研究，包括同时输注葡萄糖、胰岛素和奥曲肽3小时。在IST期间，葡萄糖和胰岛素水平达到稳态水平；这些可以直接量化胰岛素抵抗和胰岛素清除。我们将在未来的研究中研究这些特征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the proposal is to perform the insulin suppression test (IST) in 20 subjects to gain experience and train our staff. The IST is a physiologic study that involves simultaneous infusion of glucose, insulin and octreotide for 3 hours. During the IST, glucose and insulin levels reach steady state levels; these allow direct quantification of insulin resistance and insulin clearance. These are traits that we will be examining in future research studies.