Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative Supplement

这是慢性疾病联合会锡达斯-西奈U01中心的行政补充申请 由潘多尔和古达尔齐博士领导的胰腺炎、糖尿病和胰腺癌(CPDPC)。 通过其工作组的努力和 委员会。然而，需要显著加强对队列患者的招募和监测 开展CPDCP研究，以实现国家目标。本申请提供了计划和资源， 西达斯-西奈U01中心的财团将为所需的国家努力作出重大贡献。 CPDPC的主要目标是建立大量深表型患者的预期队列，具有强大的 收集生物标本，供临床医生和研究人员将来分析。队列研究一直是 由该联合会的工作组制定，包括成人和儿科确诊的慢性疾病患者 胰腺炎，疑似或可能的慢性胰腺炎，以及急性复发性胰腺炎。INSPPIRE2中的这些队列 (儿童胰腺炎国际研究小组：寻找治疗方法)(CP-RAP)(慢性 胰腺炎和复发性急性胰腺炎)儿科工作组和进程(前瞻性评估 慢性胰腺炎流行病学和转化学研究)由CP-RAP成人工作开发 小组正在积极招募受试者，这些标本和队列形成了未来研究的平台，定义 慢性病的病因学、诊断标准、自然病史、进展的预防和个体化治疗 复发性急性胰腺炎。胰腺癌风险增加的一大群患者，即新发病的患者 50岁以上糖尿病(新发糖尿病[NOD]队列)，由糖尿病和胰腺疾病发展而来 导管腺癌(DM-PDAC)工作组现在也通过CPDPC和其他 合作机构，全面收集生物标本并采取后续行动，提供基础设施 用于鉴定极早期、无症状的胰腺癌的生物标志物。由于这种癌症出现的时间较晚 并且仍然具有高度致命性，这项工作可能会为早期发现提供策略。最后，一项横断面研究 混合餐试验对继发性糖尿病的诊断和特征的评价 3c型糖尿病(T3cDM)所致的胰腺癌和慢性胰腺炎 工作组正在确定与慢性胰腺炎和糖尿病相关的激素失调 胰腺癌，以提供对这些疾病的机制和诊断标准的见解。这其中的每一个 工作组目前还在进行许多协同辅助研究，包括病因学研究， 诊断性能、生物标记物开发、机理研究和干预试验。

This is an application for an administrative supplement for the Cedars-Sinai U01 Center of the Consortium on Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) which is led Drs. Pandol and Goodarzi. There has been significant progress within the CPDPC consortium through the efforts of its working groups and committees. However, there are needs to significantly enhance recruitment and monitoring of patients for the cohort studies of CPDCP to meet national goals. The present application provides for plans and resources needed for the Cedars-Sinai U01 Center of the Consortium to make significant contributions to the required national effort. The main goals of the CPDPC are to establish large prospective cohorts of deeply phenotyped patients, with a robust collection of biospecimens for analysis by clinicians and investigators in the future. The cohort studies have been developed by the working groups of the Consortium and include both adult and pediatric patients with proven chronic pancreatitis, suspected or possible chronic pancreatitis, and acute relapsing pancreatitis. These cohorts INSPPIRE2 (INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE) developed by the (CP-RAP) (Chronic Pancreatitis and Recurrent Acute Pancreatitis) Pediatrics Working Group and PROCEED (PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies) developed by the CP-RAP Adult Working Group are actively recruiting subjects, and these specimens and cohorts form the platform for future studies defining etiology, diagnostic criteria, natural history, prevention of progression, and individualized therapy in chronic and recurrent acute pancreatitis. A large cohort of patients at increased risk of pancreatic cancer, those with new onset diabetes above the age of 50 (the New-Onset Diabetes [NOD] cohort), developed by the Diabetes and Pancreatic Ductal Adenocarcinoma (DM-PDAC) Working Group is now also recruiting through the CPDPC and other collaborating institutions, with comprehensive collection of biospecimens and follow-up to provide the infrastructure for identification of biomarkers of very early stage, pre-symptomatic pancreatic cancer. As this cancer presents late and remains highly lethal, this work may allow strategies for early detection. Finally, a cross-sectional study (Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis [DETECT]) developed by the Type 3c Diabetes Mellitus (T3cDM) Working Group is identifying the hormones dysregulated in for diabetes associated with chronic pancreatitis and pancreatic cancer, to provide insights into mechanisms and diagnostic criteria for these conditions. Each of these working groups are currently also pursuing numerous synergistic ancillary studies, including studies of etiology, diagnostic performance, biomarker development, mechanistic studies, and intervention trials.