EFFECT OF A COX-2 INHIBITOR OR AN ACE INHIBITOR ON T-CELL ACTIVATION IN HIV INFE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。艾滋病毒感染会导致慢性炎症状态和免疫系统的进行性损害。持续炎症的一个表现是持续的T淋巴细胞激活，这可能导致淋巴系统和CD4T细胞稳态的破坏(即纤维化)。在这项研究中，我们将研究抗炎药(塞来昔布)或抗纤维化药(赖诺普利)对T细胞活化和淋巴结纤维化的影响。GCRC将帮助我们在进行淋巴活检之前和之后监测受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infection causes a chronic inflammatory state and progressive damage of the immune system. One manifestation of the ongoing inflammation is continuous T lymphocyte activation, which may contribute to damage (i.e., fibrosis) of the lymphatic system and CD4T cell homeostasis. In this study we will investigate the effect of an anti-inflammatory agent (celecoxib) or an anti-fibrotic agent (lisinopril) on T-cell activation and lymph node fibrosis. The GCRC will help us to monitor subjects before and after a lymph node biopsy is performed.