METABOLIC EFFECTS OF ALCOHOL IN THE FORM OF WINE IN PERSONS WITH TYPE 2 DIABETES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。适度饮酒与降低死亡率、降低心血管疾病风险和降低2型糖尿病风险有关。然而，酒精对2型糖尿病患者的影响尚未明确界定。虽然酒精似乎不会提高血糖，但其降低血糖的潜力需要进一步研究。此外，酒精引起低血糖的可能性仍然是一个安全问题。最后，我们对酒精对糖尿病患者血脂的影响知之甚少。为了解决这些问题，提出了两个子研究。第一个子研究将检验晚餐时以葡萄酒形式饮用的酒精对餐后和夜间血糖水平的确切影响。要测试的假设是，晚餐时饮用葡萄酒会导致第二天早上空腹血糖降低。第二个子研究将检查一个月定期饮用葡萄酒对血浆脂质的影响。要验证的假设是，长期适量饮用葡萄酒形式的酒精会对血浆脂质产生有益影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of alcohol in moderation has been associated with reduced mortality rates, reduced risk of cardiovascular disease and reduced risk for type 2 diabetes mellitus. However, the effects of alcohol in persons with type 2 diabetes mellitus have not been clearly defined. Although alcohol does not appear to raise blood glucose, its potential to lower blood glucose needs further study. Moreover, the possibility of alcohol induced hypoglycemia remains a safety concern. Finally, little is known about the effects of alcohol on plasma lipids in people with diabetes. To address these issues, two substudies are proposed. The first substudy will examine the accute effects of alcohol in the form of wine at supper on postprandial and nocturnal plasma glucose levels. The hypothesis to be tested is that the use of alcohol in the form of wine with the evening meal will result in lower fasting plasma glucose the next morning. The second substudy will examine the effects of alcohol in the form of wine consumed regularly for one month on plasma lipids. The hypothesis to be tested is that the chronic use of alcohol in moderation in the form of wine will have beneficial effects on plasma lipids.