ASPERGILLLUS ANGIONVASION AND DISSEMINATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是研究真菌烟曲霉与内皮细胞的相互作用。我们的假设是A.在侵袭性曲霉病的发病机制中，烟曲霉菌与内皮细胞在血管侵袭过程中的相互作用是重要的。对于拟定的研究，将从人脐带内的静脉中收获内皮细胞，并在组织培养物中生长。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research project is to study the interactions of the fungus, Aspergillus Fumigatus, with endothelial cells. Our hypothesis is that the interactions of A. Fumigatus with endothelial cells during the process of angioninvasion are central to the pathogenesis of invasive Aspergillosis. For the proposed studies, the endothelial cells will be harvested from the veins within human umbilical cords and grown in tissue culture.