GENETIC DETERMINANTS OF ANKYLOSING SPONDYLITIS SEVERITY: CROSS SECTIONAL STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究将检查特定遗传标记与20年或以上强直性脊柱炎患者长期健康结果之间的关系。这将在一次研究访问中完成，以评估放射学和功能结果方面的疾病进展。此外，我们将测试特定遗传标记与10年或以下强直性脊柱炎患者炎症严重程度之间的关联。这些患者将被监测26个月，以评估放射学和功能预后方面的疾病进展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine associations between specific genetic markers and long-term health outcomes in patients with ankylosing spondylitis of 20 or more years. This will be done in a one time study visit to assess disease progress in terms of radiological and functional outcomes. Additionally, we will test associations between specific genetic markers and the severity of inflammation in patients with ankylosing spondylitis of 10 years or less. These patients will be monitored for 26 months to assess disease progression in terms of radiological and functional outcomes.