THE EVALUATION OF THE CLINICAL AND GLUCOSE METABOLIC RESPONSE TO ANTIDEPRESSA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。老年人抑郁症的治疗是一个重要的临床问题，因为需要长达12周的抗抑郁治疗来确定药物是否有效，许多患者治疗后没有好转。在进行扩展的临床试验之前，开发一种方法来识别对治疗无反应的患者将是一种有用的临床工具。此外，通过研究临床改善的患者，更好地了解抗抑郁药物如何在大脑中起作用，可能有助于开发更有效的药物。这些考虑是本研究的动力，旨在测量单次静脉注射抗抑郁药物（西酞普兰）后脑代谢的变化，然后在长期口服药物治疗期间。本研究的目的是比较患者对西酞普兰的急性代谢反应和对照组，并测量慢性西酞普兰治疗对患者的代谢影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The treatment of depression in the elderly represents a significant clinical problem in that it takes up to twelve weeks of antidepressant treatment to determine whether the medication is working and many patients fail to improve with treatment. The development of a method to identify patients who will not respond to treatment prior to undertaking an extended clinical trial would be a useful clinical tool. In addition, a better understanding of how antidepressant medications work in the brain by studying patients who improve clinically may help in the development of more effective medications. These considerations were the impetus for the present study designed to measure the changes in brain metabolism after a single, intravenous dose of an antidepressant medication (citalopram) and then, during chronic treatment with the oral medication.The aims of the study are to compare the acute, metabolic response to citalopram in patients to controls and to measure the metabolic effects of chronic citalopram treatment in the patients.