ASSESSMENT AND DETERMINATION OF BIOMARKERS OF INFLAMMATION IN URINE SAMPLES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究的目的是评估人类尿液中可能的炎症生物标志物。这项研究将提供有关使用尿液样本确定个体炎症状态的可行性的信息，这对于准确测量营养状况非常重要。目前测量炎症的方法是基于血浆或血清中急性期蛋白的测定，其涉及获得血液样品。然而，获取血液样本是一种侵入性程序，需要训练有素的抽血专家的专业知识。尽管如此，采血师有时可能无法进入静脉，或者血液体积有时不足以分析各种分析物。此外，有些人可能不愿意参加，因为提供血液样本，毛细血管或静脉，是不符合文化。这将是一项前瞻性研究，对象是在Ritenour大楼大学卫生服务中心诊断、治疗和入组的急性呼吸道感染（ARI）患者。登记的参与者将被要求提供血液和尿液样本后，他们的伊拉诊断立即;这些样本将在大学卫生服务，Ritenour大楼获得。然后他们将在7天和14天后来到GCRC提供血液和尿液样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to assess possible biomarkers of inflammation in human urine. This study will provide information on the feasibility in determining the inflammation status of individuals using urine samples, which is important in accurately measuring nutritional status. Current methods of measuring inflammation are based on the determination of acute phase proteins in plasma or serum, which involve obtaining blood samples. However, obtaining a blood sample is an invasive procedure that requires the expertise of a trained phlebotomist. Nonetheless, phlebotomists sometimes may fail in accessing a vein, or blood volumes are sometimes insufficient for analysis of various analytes. Additionally, some individuals may be reluctant to participate because providing a blood sample, capillary or venous, is not culturally acceptable. This will be a prospective study of patients with acute respiratory infections (ARI) diagnosed, treated, and enrolled at the University Health Services, Ritenour Building. Enrolled Participants will be asked to provide blood and urine samples immediately upon their diagnose of IRA; these samples will be obtained at the University Health Services, Ritenour Building. Then they will come to the GCRC to provide blood and urine samples 7 and 14 days later.