ALS NUTRITION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的主要目的是调查常规和早期积极营养和呼吸干预对生存、功能结局和生活质量的影响。次要目标包括开发和验证改善NIPPV(无创正压通气)耐受性的策略；评估早期呼吸功能障碍的测量方法，并确定ALS患者的能量平衡。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this study is to investigate the effect of conventional versus early aggressive nutritional and respiratory intervention on survival, functional outcome and quality of life. Secondary objectives include the development and validation of strategies to improve tolerability of NIPPV (non-invasive positive pressure ventilation); evaluation of measurements of early respiratory dysfunction and determination of energy balance in ALS.