GENETICS IN EARLY-ONSET STROKE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。虽然这项提案的重点将是检查与血管疾病相关的三种多态基因与环境的相互作用，但必须强调的是，该项目的目标和影响超出了这一局限的焦点。这项建议的长远目标是为继续研究血管疾病的遗传基础建立一个独特的资源。具体目的是：1.评估近期感染史、外周血肺炎衣原体、行为因素、家族史以及内毒素受体(CD14)、血小板膜糖蛋白受体IIb/IIIa(GPIIb-IIIa)和一氧化氮合酶(NOS)基因多态性在人群中的患病率。2.确定这些因素对缺血性卒中和缺血性卒中亚型的相对风险。3.确定近期感染、慢性肺炎衣原体感染和行为因素(如吸烟、锻炼、口服避孕药的使用、饮酒)在改变基因状态对中风风险的影响方面的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While the focus of this proposal will be to examine gene-environment interactions related to three polymorhisms associated with vascular disease, it is important to emphasize that the objectives and implications of this project extend beyond this restricted focus. The loong-range objective of this proposal is to establish a unique resource for continued studies of the genetic basis of vascular disease. Specific aims are to: 1. Estimate the prevalence in the population of history of recent infection, PCR evidence of Chlamydia pneumoniae in peripheral blood, behavioral factors, family history, and genetic polymorphisms of the endotoxin receptro (CD 14), platelet glycoprotein receptor IIb/IIIa (GpIIb-IIIa), and nitric oxide synthase (NOS). 2. Determine the relative risk of these factors for ischemic stroke and for ischemic stroke subtypes. 3. Determine the role of recent infection, chronic infection with C. pneumoniae, and behavioral factors (e.g., cigarette smoking, exercise, oral contraceptive use, alcohol intake) in modifying the effect of genotype status on stroke risk.