LIFESTYLE AMP; BIOCHEMICAL CHARACTERISTICS OF A CENTRAL OK NAT AMERICAN POP

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们将调查俄克拉何马州中部印第安人的运动和饮食习惯，通过俄克拉何马州肖尼市的公民波塔瓦托米国家健康中心招募参与者。我们还将测量与糖尿病、肥胖和代谢综合征的发展相关的各种血液值，每一个都是心血管风险的独立预测因子。我们收集的数据将确定临床人群的特征，确定进一步研究的可行性，并最终用于计划预防糖尿病、肥胖和代谢综合征发展的介入性试验。在主要的高加索人群中，强化的生活方式改变和二甲双胍已被证明可以降低糖尿病的发病率。这些干预措施还没有在美洲土著人群中进行过专门的测试。位于俄克拉何马州肖尼市的公民波塔瓦托米国家健康中心代表了一个相当独特的环境，大约有一万名印第安人在这里接受医疗保健或一般健身训练。这代表了一个理想的临床人群，在其中测试干预措施，如上面提到的印第安人。然而，为了计划干预，必须首先测量研究人群当前的运动和饮食习惯以及各种生化标志物的基线水平。具体目标#1：利用俄克拉何马州肖尼市的公民波塔瓦托米国家健康服务诊所和Firelake健康中心，表征印第安人的饮食和运动习惯，并选择体检和心血管风险的生化预测指标。具体目标2：确定进一步研究的可行性，特别是在招聘方面。具体目标#3：为预防肥胖、糖尿病和代谢综合征制定实用有效的干预建议，并可在未来的临床试验中进行测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will survey the exercise and eating habits of the central Oklahoma Native American population recruiting participants through the Citizen Potawatomi Nation Health Center in Shawnee, Oklahoma. We will also measure a variety of blood values that are associated with the development of diabetes, obesity, and the metabolic syndrome, each being an independent predictor of cardiovascular risk. The data we collect will characterize this clinical population, determine the feasibility for further study and, ultimately, be used to plan an interventional trial to prevent the development of diabetes, obesity, and the metabolic syndrome. A. Specific Aims Intensive lifestyle modification and metformin have been shown to decrease the incidence of diabetes mellitus in a primarily Caucasian population. Such interventions have not been specifically tested in a Native American population. The Citizen Potawatomi Nation Health Complex in Shawnee, Oklahoma represents a fairly unique setting in which approximately ten-thousand Native Americans access health care or general fitness training. This represents an ideal clinical population in which to test interventions such as those mentioned above on Native Americans. However, in order to plan an intervention, the current exercise and dietary habits of the study population as well the baseline levels of a variety of biochemical markers must first be measured. Specific aim #1: Characterize the dietary and exercise habits and selected physical exam and biochemical predictors of cardiovascular risk in the Native Americans utilizing the Citizen Potawatomi Nation Health Services Clinic and Firelake wellness Center in Shawnee, Oklahoma. Specific aim #2: Establish feasibility of further study, especially in terms of recruitment, of this population. Specific aim #3: Formulate a recommendation for a practical and effective intervention to prevent obesity, diabetes, and the metabolic syndrome that can be tested in a future clinical trial.