CREATINE1

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们对人类大脑中线粒体功能改变的代谢影响感兴趣，这可能与使用肌酸等补充剂有关。口服肌酸作为膳食补充剂已使用多年，主要用于运动训练；然而，已经积累的大量证据表明，它也可能对大脑功能产生积极影响（例如，它已被证明可以改善认知表现）。本项目拟在补充肌酸的同时对健康受试者和癫痫患者进行研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the metabolic effects of altered mitochondrial function in the human brain, which may occur with utilization of supplements such as creatine. Oral creatine has been used for many years as a dietary supplement primarily for athletic training; however considerable evidence has accumulated that it may also favorably affect cerebral function (for example, it has been shown to improve cognitive performance). In this project, it is proposed that healthy subjects and epilepsy patients will be studied while on creatine supplementation.