MR OF BRAIN

大脑先生

• 批准号: 7375472
• 负责人: Jullie W Pan
• 金额: $ 2.86万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375472
• 关键词: MR; BRAIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has developed optimal approaches to the reproducible magnetic resonance study of the hippocampus for imaging and spectroscopic studies. In particular, repeated and longitudinal evaluation of the hippocampus is important for studies in epilepsy and aging, amongst other neurological diseases. Thus this project has developed wholly obliqued imaging together with analysis software to co-register and consistently evaluate hippocampal metabolism in a semi-automated fashion. While the literature demonstrates 10-20% CV in whole hippocampal studies, demonstration of the obliqued-co-registered approach in n=10 control volunteers (each studied twice) provide a standard deviation of difference of 9% for individual hippocampal voxels and 3.5% over the entire hippocampus. This work has been accepted as a platform discussion to the Int'l Society for Magnetic Resonance 2004 and has been submitted Magn Res Medicine, citing the GCRC.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目开发了用于成像和光谱研究的海马体可重复磁共振研究的最佳方法。特别是，海马体的重复和纵向评估对于癫痫和衰老以及其他神经系统疾病的研究非常重要。因此，该项目开发了全自动成像和分析软件，以半自动方式共同记录和一致地评估海马代谢。虽然文献证明整个海马体研究中的CV为10-20%，但在n=10名对照志愿者（每个志愿者研究两次）中证实的双配准方法提供了单个海马体素9%的差异标准差和整个海马体3.5%的差异标准差。这项工作已被接受为2004年国际磁共振学会的平台讨论，并已提交给Magn Res Medicine，引用GCRC。