MR OF BRAIN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目开发了用于成像和光谱研究的海马可重复磁共振研究的最佳方法。特别是，海马体的重复和纵向评估对于癫痫和衰老以及其他神经系统疾病的研究非常重要。因此，该项目开发了完全斜向成像和分析软件，以半自动化的方式共同记录和一致评估海马代谢。虽然文献显示整个海马研究中CV值为10-20%，但在n=10个对照志愿者（每个研究两次）中，斜向共登记方法的证明为单个海马体素的标准差为9%，整个海马体素的标准差为3.5%。这项工作已被国际磁共振学会（international Society for Magnetic Resonance）接受为2004年的讨论平台，并已提交给《医学杂志》（Magn Res Medicine），引用GCRC。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has developed optimal approaches to the reproducible magnetic resonance study of the hippocampus for imaging and spectroscopic studies. In particular, repeated and longitudinal evaluation of the hippocampus is important for studies in epilepsy and aging, amongst other neurological diseases. Thus this project has developed wholly obliqued imaging together with analysis software to co-register and consistently evaluate hippocampal metabolism in a semi-automated fashion. While the literature demonstrates 10-20% CV in whole hippocampal studies, demonstration of the obliqued-co-registered approach in n=10 control volunteers (each studied twice) provide a standard deviation of difference of 9% for individual hippocampal voxels and 3.5% over the entire hippocampus. This work has been accepted as a platform discussion to the Int'l Society for Magnetic Resonance 2004 and has been submitted Magn Res Medicine, citing the GCRC.