AN OBSERVATIONAL COHORT STUDY TO PREDICT PREECLAMPSIA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。先兆子痫仍然是胎儿和产妇发病率和死亡率的主要原因，也是最常见的妊娠并发症之一。目前既没有有效的方法来确定有患先兆子痫风险的妇女，也没有有效的治疗方法。很少有纵向研究衡量先兆子痫的潜在预测因素。该方案测量了潜在的生物化学和生物物理标记物，用于预测低风险未产妇的子痫前期。这项研究是一项观察性队列(预测)研究，将招募4,000名未分娩的低风险孕妇，她们孕周在9至12周之间，并已登记参加联合抗氧化剂先兆子痫预测研究的随机临床试验。将收集和储存体液，以供随后的分析，这些分析可以以嵌套病例对照的方式进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preeclampsia remains a major cause of fetal and maternal morbidity and mortality and is one of the most common complications of pregnancy. There is currently neither an effective method of identifying women at risk for developing preeclampsia nor an effective treatment. There are few longitudinal studies measuring potential predictors of preeclampsia. This protocol measures potential biochemical and biophysical markers for prediction of preeclampsia in nulliparous women at low risk for developing preeclampsia. This study is an observational cohort (prediction) study which will recruit four thousand nulliparous pregnant women at low risk for developing preeclampsia who are between 9 and 12 weeks gestational age and whom have been enrolled in the Randomized Clinical Trial of Combined Antioxidant Preeclampsia Prediction Study. Body fluids will be collected and stored for subsequent analyses which can be performed in a nested case control manner.