PROSTATE CANCER CHEMOPREVENTION TRIAL

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项随机、双盲化学预防试验的目的是确定大豆蛋白化学预防治疗是否会降低或延迟PSA的进一步上升，这些男性的PSA失败是前列腺癌根治性前列腺切除术后疾病复发的第一个迹象。第二个目的是确定大豆蛋白的化学预防治疗是否会延迟根治性前列腺切除术后的前列腺癌复发，因为前列腺癌具有不利的特征，因此在复发风险高的男性中，PSA失败表明。大豆蛋白降低复发率的能力以及RT-PCR检测到的循环前列腺癌细胞的数量将被确定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this randomized, double-blind chemoprevention trial are to determine whether chemopreventive treatments with soy protein reduce or delay further rise in PSA in men that present with a PSA failure as the first sign of disease recurrence following radical prostatectomy for prostate cancer. A second objective is to determine whether chemopreventive treatment with soy protein delays prostate cancer recurrence following radical prostatectomy, as indicated by PSA failure in men who are at high risk for recurrrence because their cancers have unfavorable characteristics. The ability of soy protein to reduce the frequency of recurrence and the quantity of circulating prostate cancer cells detected by RT-PCR will be determined.