PROSTATE CANCER CHEMOPREVENTION TRIAL

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项随机双盲化学预防试验的目的是确定大豆蛋白的化学预防治疗是否减少或延迟PSA的进一步上升，PSA失败是前列腺癌根治性前列腺切除术后疾病复发的第一个迹象。第二个目的是确定大豆蛋白的化学预防治疗是否延迟前列腺癌根治术后的复发，如PSA失败所示，因为他们的癌症具有不利的特征，因此具有高复发风险。将确定大豆蛋白降低复发频率的能力和通过RT-PCR检测的循环前列腺癌细胞的数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this randomized, double-blind chemoprevention trial are to determine whether chemopreventive treatments with soy protein reduce or delay further rise in PSA in men that present with a PSA failure as the first sign of disease recurrence following radical prostatectomy for prostate cancer. A second objective is to determine whether chemopreventive treatment with soy protein delays prostate cancer recurrence following radical prostatectomy, as indicated by PSA failure in men who are at high risk for recurrrence because their cancers have unfavorable characteristics. The ability of soy protein to reduce the frequency of recurrence and the quantity of circulating prostate cancer cells detected by RT-PCR will be determined.