PROSTATE CANCER CHEMOPREVENTION TRIAL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项随机、双盲的化学预防试验的目的是确定在前列腺癌根治性前列腺癌切除术后出现PSA失败的男性患者中，使用大豆蛋白进行化学预防治疗是否可以降低或延缓PSA的进一步升高。第二个目标是确定使用大豆蛋白进行化学预防治疗是否会延迟前列腺癌根治术后的复发，这一点从PSA失败的男性身上可以看出，因为他们的癌症具有不利的特征，因此复发的风险很高。将确定大豆蛋白降低复发频率的能力，以及RT-PCR检测到的循环前列腺癌细胞数量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this randomized, double-blind chemoprevention trial are to determine whether chemopreventive treatments with soy protein reduce or delay further rise in PSA in men that present with a PSA failure as the first sign of disease recurrence following radical prostatectomy for prostate cancer. A second objective is to determine whether chemopreventive treatment with soy protein delays prostate cancer recurrence following radical prostatectomy, as indicated by PSA failure in men who are at high risk for recurrrence because their cancers have unfavorable characteristics. The ability of soy protein to reduce the frequency of recurrence and the quantity of circulating prostate cancer cells detected by RT-PCR will be determined.