MAGNETOENCEPHALOGRAPHIC STUDIES OF NEUROLOGIC & PSYCHIATRIC PATIENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。感官知觉和意识的过程是一种高度进化的精神状态，可以被描述为生物体对其内部或外部环境表征的意识。正常意识过程背后的神经机制，以及它们在神经和精神疾病中的破坏程度还远未被理解。本协议旨在确定和阐述丘脑皮质过程的神经生理学。这个范围从感觉和认知事件的正常处理，到可导致神经或精神症状的丘脑皮质功能障碍的部分异常，到植物人状态下的断开连接。患者将沿着神经和精神疾病的连续性被招募。将尝试用脑磁图来描述患有慢性、严重和治疗抵抗性神经和精神疾病的受试者与正常对照组相比，大脑活动的差异。将尝试将特征活动定位到大脑内的区域，以揭示参与异常神经生理学产生的丘脑皮质回路。希望发展一种客观的脑磁图分析方法来识别和监测症状的来源

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The process of sensory perception and consciousness is a highly evolved mental state that can be described as an organism's awareness of representations of its internal or external environment. The neural mechanisms underlying normal conscious processes, and the degrees of their disruption in neurologic and psychiatric diseases are far from understood. This protocol aims to identify and elaborate the neurophysiology of thalamocortical processes. This range extends from the normal processing of sensory and cognitive events, through partial aberrations in thalamocortical dysfunction which can lead to neurological or psychiatric symptoms, to a disconnection in the vegetative state. Patients will be recruited along the continuum of neurologic and psychiatric illness. An attempt will be made to characterize with MEG the differences in brain activity between subjects suffering from chronic, severe, and therapy-resistant neurologic and psychiatric disorders, compared to activity in normal controls. An attempt will be made to localize characterized activity to regions within the brain in order to uncover the thalamocortical circuits involved in the generation of abnormal neurophysiology. An objective magnetoencephalographic assay to identify and monitor the source of symptoms is hoped to be develope