DEPOT MEDROXYPROGESTERONE ACETATE AND BONE MINERAL DENSITY IN ADOLESCENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在我们之前的研究中，我们发现醋酸甲羟孕酮与青春期女孩的骨密度丢失有关。从NIH审查员的反馈到与之竞争的续签申请，我们推断，任何可以给我们提供关于停止该方法的女孩骨骼反应的信息的数据，都将有助于我们证明在我们的下一个资金周期中检查这些女孩骨骼恢复前景的重要性。因此，这项研究的目的是招募我们之前研究中确定的9名女孩，特别是那些脊柱骨密度下降5%且目前没有接受药物治疗的女孩，进行重复的DEXA(双能量吸收法)测试。其目的是将当前的DEXA结果与先前研究中获得的结果进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In our previous study, we found that depot medroxyprogesterone acetate was associated with loss in bone mineral density in adolescent girls. From feedback of reviewers at the NIH to a competing renewal application, we deduce that any data that would give us information about the response of bone in girls who discontinue the method would be helpful in our demonstrating the importance of our examining the prospect of recovery of bone in these girls in our next funding cycle. Therefore, the objective of this study is to recruit the 9 girls identified in our previous studies, specifically those who dropped >5% in bone mineral density at the spine and who are not currently receiving the drug, for a repeat DEXA (dual energy absorptiometry) test. The purpose is to compare the current DEXA result with those that were obtained in the previous study.