FOLLOW-UP OF VERY LOW BIRTHWEIGHT INFANTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。现代围产期护理方法提高了高危婴儿的存活率。在过去，这些婴儿在神经受损人群中所占比例过高。本研究的目的是(1)对这些婴儿进行随访评估(2)提供必要的早期干预(3)评估在新生儿护理环境中使用的新方法的效果。本研究除了使用GCRC的门诊设施外，还使用了发育试验室。婴儿在出院前进行检查，然后在40周、4个月和8个月矫正年龄进行检查。在8个月的访问中进行贝利发育评估。此后，婴儿在20个月矫正年龄时进行身体、神经和贝利发育评估。在婴儿期使用的神经检查方法是由巴黎的阿米尔·蒂松博士开发的。它是在婴儿出生后的第一年按顺序进行的，可以将婴儿分为正常组、可疑组和异常组。第一年之后，使用标准的儿科神经检查。被定义为神经异常的婴儿包括张力低下、脑瘫、脑积水或抽搐。脑瘫被定义为痉挛性双瘫或四肢瘫痪。双瘫是一种对称的痉挛性双瘫，腿部比手臂受影响更大。四肢瘫痪时，手臂比腿部受影响更大。结果通过(1)主要中枢神经系统异常（包括脑瘫、脑积水、癫痫和其他相关病变）的发生率来衡量，(2)通过Bayley试验测量的智力功能水平。记录社会、产前和围产期因素，并记录住院期间的新生儿重症监护事件。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Modern methods of perinatal care have resulted in an increased survival of high risk infants. These infants have in the past contributed disproportionately to the neurologically impaired population. The purposes of this study are to (1) provide follow-up assessment of these infants (2) provide for early intervention if required and (3) assess the effects of new methods utilized in neonatal care settings. This study uses the developmental testing room in addition to the outpatient facilities of the GCRC. Infants are examined before discharge and then at 40 weeks, 4 months, and 8 months corrected age. At the 8 month visit a Bayley Developmental Assessment is performed. Thereafter, the infant is seen at 20 months corrected age for a physical, neurological, and a Bayley developmental assessment. The method of neurological examination utilized during infancy is that developed by Dr. Amiel Tison of Paris. It is employed sequentially during the infant's first year of life and permits the classification of infants into normal, suspect and abnormal groups. After the first year a standard pediatric neurologic examination is utilized. Infants defined as neurologically abnormal include those with hypotonia, cerebral palsy, hydrocephalus or convulsions. Cerebral palsy is defined as spastic diplegia or quadriplegia. With diplegia there is a symmetrical spastic diparesis, the legs more affected than the arms. With quadriplegia the arms are more affected than the legs. Outcome is measured by (1) the incidence of major central nervous system abnormalities including cerebral palsy, hydrocephalus, epilepsy and other related lesions, (2) the level of intellectual function as measured by Bayley tests. Social, antenatal and perinatal factors are documented and neonatal intensive care events are recorded during the hospital stay.