BIOMAGNETIC CHARACTERIZATION OF GASTRIC DYSRHYTHMIAS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。假说（ES）： 1)胃电活动（GEA）在胃平滑肌合胞体中有规律的时空模式传播。2)正常组织内的胃内电模式产生规律的胃外磁场模式。3)正常人的胃电模式在多通道外磁场记录下产生规则的时空模式。4)胃合胞体机械解偶联引起的胃节律障碍在内膜电位和外磁场记录中产生不规则的时空模式。5)已知引起胃节律异常的自主神经紊乱导致胃磁场时空模式异常。6)与正常志愿者相比，糖尿病胃轻瘫患者餐后胃磁场模式异常。具体目的：1)表征正常人类志愿者GEA的磁模式。2)描述自主神经紊乱对胃磁场模式的影响。3)糖尿病性胃轻瘫的磁共振特征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESIS(ES): 1) Gastric electrical activity (GEA) propagates in the smooth muscle syncytium of the stomach in regular spatiotemporal patterns. 2) Internal gastric electrical patterns in normal tissue produce regular external gastric magnetic field patterns. 3) Gastric electrical patterns in normal humans produce regular spatiotemporal patterns in multichannel external magnetic field recordings. 4) Gastric dysrhythmias resulting from mechanical uncoupling of the gastric syncytium produce irregular spatiotemporal patterns in recordings of both internal serosal potentials and external magnetic fields. 5) Autonomic disorders known to cause gastric dysrhythmias result in abnormal gastric magnetic field spatiotemporal patterns. 6) Patients w/diabetic gastroparesis exhibit abonormal postprandial gastric magnetic field patterns compared to normal volunteers. SPECIFIC AIMS: 1) Characterize magnetic patterns of GEA in normal human volunteers. 2) Characterize the effect of autonomic disorders on gastric magnetic field patterns. 3) Characterize the magnetic signature of diabetic gastroparesis.