ACETAMINOPHEN AND ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。1.长期使用治疗剂量的对乙酰氨基酚会引起人体呼吸道的氧化应激。2.长期使用治疗剂量的对乙酰氨基酚会导致人体呼吸道内收缩支气管前列腺素的浓度增加。具体目的1.验证长期使用治疗性剂量的对乙酰氨基酚会在正常人和哮喘患者的呼吸道中引发氧化应激的假设。2.验证长期使用治疗剂量的对乙酰氨基酚可抑制前列环素并增加哮喘患者呼吸道血栓素A2水平的假说。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1. Prolonged use of acetaminophen in therapeutic doses provokes oxidative stress in human airways. 2. Prolonged use of therapeutic doses of acetaminophen results in increased concentrations of bronchoconstricting prostanoids in human airways. Specific aims 1. To test the hypothesis that chronic use of acetaminophen in therapeutic doses provokes oxidative stress in the airways in normal and asthmatic human subjects. 2. To test the hypothesis that chronic use of therapeutic doses of acetaminophen causes inhibition of prostacyclin and increases thromboxane A2 levels in the airways in normal and asthmatic subjects.