GHRELIN LEVELS WITH ORAL VS PER TUBE MEALS AFTER RYGB

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。具体目标确定胃分裂对病态肥胖患者胃饥饿素释放的时间依赖性影响。2. 确定在RYGB期间胃分裂导致的胃底分离是否会改变病态肥胖患者进食后术后早期胃饥饿素的分泌模式。3. 确定眼底在调节血浆胃饥饿素水平的昼夜变化中的潜在作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims 1. Determine the time-dependent impact of gastric division on ghrelin release in the morbidly obese patient. 2. Determine whether gastric division with resultant fundic isolation during RYGB would alter the pattern(s) of ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects. 3. Determine the potential role of the fundus in mediating the diurnal variation in plasma ghrelin levels.