HIV-PNEUMONIAE IMMUNITY STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项2：1匹配的病例对照研究，研究时间跨度为拨款的头两年。病例均为痰或任何无菌部位肺炎链球菌培养阳性的患者。病例和对照将按年龄和以前接种肺炎球菌疫苗的病史进行分层。此外，HIV血清阳性患者将与CD4淋巴细胞计数层匹配进行亚群分析。根据我们的初步数据，我们预计在病例对照研究中总共招募180名受试者，包括辍学和退出。我们将使用两样本t检验或Mann-Whitney U检验来比较黑人和非黑人之间的抗体水平及其功能。在多元回归模型中，我们将评估侵袭性肺炎球菌疾病和耐青霉素肺炎链球菌感染的危险因素和结果决定因素。研究对象将在纳什维尔综合医院住院的患者中招募，纳什维尔综合医院是一家三级学术医疗中心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a 2:1 matched case-control study to span over the first 2 years of the grant. Cases are all patients with apositive culture for S. pneumoniae isolated from sputum or any sterile sites. The cases and controls will be stratified by age and history of previous pneumococcal vaccination. Moreover, HIV-seropositive patients will be matched by CD4 lymphocyte count stratum for subgroup analysis. Based on our preliminary data, we expect to enroll a total of 180 subjects in the case-control study, including drop-outs and withdrawals. We will use two-sample t-test or Mann-Whitney U test to compare antibody levels and their functionality between blacks and non-blacks In a multipe regression model, we will assess risk factors and outcome dterminants for invasive pneumococcal disease and infectios with penicillin resistant S. pneumoniae. Study subjects will be recruit among patients hospitalized at Nashville General Hospital, a tertiary academic medical center.