CHARACTERIZATION OF TOLLOID-LIKE PROTEIN IN REPTILE AND ITS ROLE IN SYNAPTIC PLA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。学习和记忆与形态变化有关，例如新神经元的诞生(神经发生)或新树突棘或突触的生长和形成(突触发生)。神经系统的这种长期变化涉及到神经营养因子，如脑源性神经营养因子(BDNF)和骨形态发生蛋白(BMPs)。BMP的作用至少部分受Tolloid金属蛋白家族成员的调控。Tolloid家族蛋白是一种多效性的、类似于ASTIN的金属蛋白酶。已知的哺乳动物Tolloid蛋白有四种：BMP-1、哺乳动物Tolloid(MTLD)、哺乳动物Tolloid-1(Tll-1)和哺乳动物Tolloid-2(Tll-2)。该家族的两个成员，BMP-1和TLL-1，允许BMP信号的增强。我们假设哺乳动物的Tolloid蛋白可能通过调节BMP信号而在学习过程中作为突触发生的局部增强剂发挥作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Learning and memory is associated with morphological changes such as the birth of new neurons (neurogenesis) or the growth and formation of new dendritic spines or synaptic contacts (synaptogenesis). Such long-term changes in the nervous system involve neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and the bone morphogenetic proteins (BMPs). The actions of the BMPs are regulated, at least in part by members of the Tolloid family of metalloproteases. Tolloid family proteins are pleiotropic, astacin-like metalloproteases. There are four known mammalian Tolloid proteins: BMP-1, mammalian Tolloid (mTLD), mammalian Tolloid-like 1 (Tll-1), and mammalian Tolloid-like 2 (Tll-2). Two members of the family, BMP-1 and Tll-1, allow the potentiation of BMP signaling. We hypothesize that mammalian Tolloid proteins may function as a local potentiator of synaptogenesis during learning by regulating BMP signaling.