Cobre for Signal Transduction and Cancer

描述（由申请人提供）：癌症对西弗吉尼亚州和阿巴拉契亚州公民的影响不成比例，宫颈癌、肺癌、头颈癌、卵巢癌和乳腺癌的地区健康差异证明了这一点。玛丽·巴布·伦道夫癌症中心（MBRCC）成立于西弗吉尼亚大学，旨在解决西弗吉尼亚和阿巴拉契亚地区的癌症问题。为了实现这一目标，我们计划建立一个符合NCI指定标准的癌症中心，作为我们服务不足的人群的临床癌症中心。NCI指定的癌症中心的建立是为了领导与癌症的斗争，证据是：(a)强大的基础和临床研究项目，(b)积极的癌症预防和控制项目，(c)积极的临床试验项目。我们的COBRE项目第一阶段的目标是通过发展一个强大的、有凝聚力的和活跃的基础癌症研究项目，促进NCI指定为临床癌症中心的机构目标。在第一阶段，MBRCC协调了癌症中心的成员资格和项目组织，为试点项目提供配套支持，为新聘用的教师提供核心设施和实验室/办公空间。此外，西弗吉尼亚大学健康科学中心为新聘的教职员工提供终身教职，并为启动包、行政支持、实验室和核心设施的翻新以及核心设备的资金提供资源。在第一阶段，COBRE为五个初级教师研究项目提供支持，为新教师和现有教师提供核心设施基础设施，并为教师招聘提供配套资金。在第一阶段，我们成功地招募了8名新教员，指导5名初级教员获得独立的RPG基金，建立了两个新的核心设施，并扩大了第三个核心设施的范围。在这个续期申请（II期）中，我们寻求增加基础科学研究项目的深度，并将其与转化研究计划相结合，努力在西弗吉尼亚大学建立一个NCI指定的临床癌症中心。我们寻求支持(1)由经验丰富的癌症研究科学家组成的管理核心，(2)由初级教师领导的五个癌症研究项目，以及(3)支持MBRCC研究项目的蛋白质组学，流式细胞术和生物信息学三个核心设施。这些目标的实现将有助于MBRCC建立一个NCI指定的临床癌症中心，为西弗吉尼亚州和周边的阿巴拉契亚地区服务。

DESCRIPTION (provided by applicant): Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by regional health disparities in cervical, lung, head & neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address the cancer problem in West Virginia and Appalachia. Toward that goal we plan to establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center for our underserved population. NCI designated Cancer Centers were established to lead the fight against cancer as evidenced by (a) strong basic and clinical research programs, (b) an active cancer prevention and control program and (c) an active clinical trials program. The goal of the first phase (Phase I) of our COBRE program was to foster institutional goals for NCI designation as a Clinical Cancer Center through the development of a strong, cohesive and active basic cancer research program. In Phase I, the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, Core facilities and laboratory/office space for new faculty hires. In addition, the West Virginia University Health Sciences Center committed tenure-track faculty lines for new faculty hires and resources for startup packages, administrative support, renovations for labs and Core facilities and funds for Core equipment. During Phase I, the COBRE provided support for five junior faculty research projects, Core facility infrastructure for new and existing faculty and matching funds for faculty recruitment. In Phase I, we were successful in recruiting 8 new faculty members, mentoring 5 junior faculty members to independent RPG funding, establishing two new Core facilities and expanding the scope of a 3rd Core facility. In this renewal application (Phase II), we seek to add depth to our basic science research program and to integrate it with translational research initiatives, in an effort to establish an NCI designated Clinical Cancer Center at West Virginia University. We seek support for (1) an administrative Core of experienced cancer research scientists, (2) five cancer research projects led by junior faculty and (3) three Core facilities in proteomics, flow cytometry and bioinformatics that support the MBRCC research programs. Accomplishment of these goals will help the MBRCC to establish an NCI designated Clinical Cancer Center that serves West Virginia and the surrounding Appalachian region.