UNIVERSITY OF NEBRASKA AT OMAHA - BIOLOGY AND COMPUTER SCIENCE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。UNO生物学有三位INBRE同事，William Tapprich， Elaine Lahue和Donald Rowen。塔普里奇博士负责管理这笔资金。Drs。Tapprich和Rowen是传染病主题的成员Lahue博士是细胞信号主题的成员。所有同事都向国际期刊提交了稿件，并且他们的稿件都被接受发表。Tapprich博士有两份出版物，一份在微生物学和免疫学的当前主题，一份在病毒学杂志。Rowen博士在微生物学杂志上发表了一篇论文。Lahue博士在酵母杂志上发表了一篇文章。所有的同事也在国内和国际会议上展示他们的工作。现在有六个BRIN学者在UNO生物学，Dan Reimer, Zachary Meyer, Joel Rivas, Kara Gordon， Ben Hanzel和Megan Nelson。前四名学生将于2005年5月毕业。Dan和Zach已经被UNMC医学院录取，Joel还没有决定他未来的计划，Kara在攻读博士学位之前将作为一名研究技术人员工作一年。所有目前的学者都积极参加并在国内和国际会议上展示他们的研究工作。卡拉和扎克获得了部门优秀专业奖，卡拉获得了今年的UNO优秀本科生奖。新入选的三位学者分别是马库斯·芬奇、苔丝·埃德姆和莫娜·索劳里。所有人都将在UNMC开始暑期项目。INBRE赠款提供的资金使我们能够在该部门建立一个DNA测序设施和一个定量实时PCR设施。来自INBRE拨款的供应和旅行资金对于维持我们的研究项目是无价的，并直接导致今年将出现的出版物。联合国大学计算机科学系继续在生物信息学领域取得重大发展。在新开发的生物信息学项目中，有5名教师（包括4名INBRE同事）、10名研究生和20名本科生（包括5名BRIN学者）的贡献，生物信息学活动正在继续发展。INBRE的四位同事（Hesham Ali, Zhengxin Chen， Parvathi Chundi和Mark Pauley）一直非常活跃于生物信息学的领先研究和教育活动。除了这四位同事之外，另一位计算机科学教师郭鹤峰也对该领域表现出了兴趣，并进行了研究。该小组的研究成果非常显著，在几个专业会议上提出了研究成果，并在三个期刊和许多参考会议论文集上发表。他们一直在指导一些研究生，其中包括五名博士生。此外，最近两个学期开设了三门新的生物信息学课程。此外，一名新的生物信息学研究员刘国清将于今年夏天加入联合国大学，他是计算机科学系和生物系联合任命的。两位2004年BRIN学者（Nicholas Palermo和Sarfraz Chandio）继续从事与去年夏天进行的项目相关的项目。在若干区域活动和两次国际会议上介绍了这些项目的成果。今年夏天，两位学者将在他们去年夏天加入的研究实验室继续他们的活动。从七名申请者中选出三名新的BRIN学者，并将于今年夏天加入研究实验室。这三位学者都是UNO生物信息学新学位的20名学生中的一员。新的学位已经吸引了许多优秀的学生，预计在未来几年将迅速增长。计算机科学系继续拥有一个重要的计算设备，该设备是由早期的BRIN拨款和NSF EPSCoR基础设施拨款开发的。集群计算设施满足生物信息学学生和教师的所有研究和教育需求。目前正在研究若干备选办法，以升级和维护这些设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UNO biology has three INBRE associates, William Tapprich, Elaine Lahue and Donald Rowen. Dr. Tapprich administers the grant. Drs. Tapprich and Rowen are members of the infectious disease theme and Dr. Lahue is a member of the cell signaling theme. All associates have submitted manuscripts to international journals and all have had their manuscripts accepted for publication. Dr. Tapprich has two publications in press, one in Current Topics in Microbiology and Immunology and one in Journal of Virology. Dr. Rowen has a publication accepted in Microbiology. Dr. Lahue has a publication accepted in Yeast. All of the associates are also presenting their work at national and international meetings. There are now six BRIN scholars in UNO biology, Dan Reimer, Zachary Meyer, Joel Rivas, Kara Gordon, Ben Hanzel, and Megan Nelson. The first four will be graduating in May 2005. Dan and Zach have been accepted into medical school at UNMC, Joel is still undecided about his future plans and Kara will work for a year as a research technician before pursuing a Ph.D. All of the current scholars have been active in attending and presenting their research work at national and international meetings. Kara and Zach were recipients of the departmental awards for outstanding major and Kara received this year's award as the outstanding undergraduate at UNO. Three new scholars have been selected for the coming year, Marcus Finch, Tess Eidem and Mona Sorouri. All will begin summer projects at UNMC. Funds made available from the INBRE grant enabled us to establish a DNA sequencing facility and a quantitative real time PCR facility in the department. Supply and travel funds from the INBRE grant are invaluable in maintaining our research programs and have led directly to the publications that will appear this year. The computer science department at UNO continues to develop significantly in the area of Bioinformatics. The Bioinformatics activities are continuing to grow with the contribution of five faculty members (including four INBRE associates), ten graduate students and twenty undergraduate students in the newly developed Bioinformatics programs (including five BRIN scholars). The four INBRE associates (Hesham Ali, Zhengxin Chen, Parvathi Chundi and Mark Pauley) have been very active in leading research and educational activities in Bioinformatics. In addition to the four associates, another computer science faculty member, Heifeng Guo, has shown interest and has conducted research in the field. The research output of the group has been significant, with results presented in several professional meetings and published in three journals and many referred conference proceedings. They have been supervising a number of graduate students including five doctoral students. Additionally, three new courses in Bioinformatics were developed and offered the last two semesters. Also, a new Bioinformatics researcher, Guoqing Liu, will be joining UNO this summer on a joint appointment between the departments of Computer Science and Biology, The two 2004 BRIN (Nicholas Palermo and Sarfraz Chandio) Scholars continued to work on projects related to the ones conducted last summer. The results of the projects were presented in several regional events as well as in two international conferences. This summer, both scholars will continue their activities at the same research labs they joined last summer. Three new BRIN Scholars were selected from seven applicants and will join research labs this coming summer. All three scholars are among the 20 students on the new degree in Bioinformatics offered at UNO. The new degree has been attracting many outstanding students and is expected to grow rapidly in the next couple of years. The computer science department continues to house a significant computational facility that was developed by funds from an earlier round of the BRIN grant and an NSF EPSCoR infrastructure grant. The cluster computing facility serves all research and educational needs of the Bioinformatics students and faculty. Several options are currently been investigated to upgrade and maintain the facilities.