MODELING OF A CEMENTED TOTAL HIP ARTHROPLASTY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目的目的是扩大以前在骨科手术中使用聚甲基丙烯酸甲酯(PMMA)进行骨替代、增强和间隔的研究。应用于本研究的策略是对股骨或全髋关节置换术(THA)的几种情况进行有限元分析(FEA)和热传递建模(HTM)。美国每年进行的全髋关节置换手术超过12.5万例，为了减轻髋关节创伤或退行性变的症状，从工程角度分析这一手术过程是非常重要的。许多全髋关节置换手术仍在进行中，使用PMMA作为一种固化剂，使股骨假体与股骨假体结合在一起，预计在大多数情况下可以缓解大约10年的症状。这些PMMA骨水泥在与液体化学硬化剂混合后会产生相当大的热量，温度达到115摄氏度以上，时间为300至800秒。此外，根据固化方法的不同，获得不同的硬化特性。基于这些特点，我们计划通过对平均大小的股骨人工髋关节进行三维计算机模拟，来研究骨水泥全髋关节置换术中的热/温度和力/应力现象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to expand previous research in the use of Polymethyl methacrylate (PMMA) for bone replacement, augmentation, and spacing in orthopedic surgery. The strategy applied to this research is to conduct finite element analysis (FEA) and heat transfer modeling (HTM) for several case scenarios of femoral or total hip arthroplasty (THA). With more than 125,000 total hip arthroplasty procedures undertaken each year in the United States, in order to alleviate the symptoms of trauma or degeneration of the hip it, is very important to analyze this surgical procedure from an engineering point of view. Many THA procedures are still being done using PMMA as an agent to solidify the bone with the femoral stem component in which it is expected to alleviate symptoms for about 10-years in most cases. These PMMA bone cements generate considerable heat, reaching temperatures of over 115oC, between 300 and 800 seconds after mixing with a liquid chemical hardener. Also, depending upon the curing method, different hardening properties are attained. Based upon these characteristics, we plan to investigate both the heat/temperature and force/stress phenomena a cemented total hip arthroplasty undergoes using three-dimensional computer simulations of an average size femoral hip replacement.