BIOINFORMATICS/MICROARRAY SATELLITE CORE-OSU

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。俄克拉荷马州立大学（OSU）微阵列核心设施（OMCF）及其相关的生物信息学小组BioinfOSU提供设施、咨询、教育和培训。他们的设备包括用于制备寡核苷酸和多核苷酸微阵列的现代仪器，用于将它们与标记的目标核酸杂交，用于扫描杂交后斑点的荧光强度以及对结果进行计算分析。员工包括一位具有丰富生物信息学经验的博士级微阵列专家，一位精通微阵列数据处理的应用程序程序员和一位系统管理员。为了证明这些人员和设施能够促进和促进功能基因组学的研究，OMCF和BioinfOSU为各级研究人员提供讲习班和咨询服务，并使其资源普遍可用。由超过25名首席研究人员领导的小组使用俄勒冈州立大学的微阵列和生物信息学设施来研究各种各样的生物：美国Amblyomma americanum（孤星蜱），空肠弯曲杆菌，Cynodon dactylon（百慕大草），Emericella nidulans, Gossypium hirsutum（棉花），流感病毒，Lycopersicon esculentum（番茄），Rattus norvegicus（老鼠），高粱，Synechocystis sp. PCC6803, Triticum aestivum（面包小麦）和各种致病微生物。该基金支持的工作已在同行评议的期刊上发表（见G节）。除了培养研究生和博士后外，领导这些实验室的科学家每年还欢迎众多本科生到他们的实验室参与研究。客户的反馈不断改善设施？提供服务和建议的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Oklahoma State University (OSU) Microarray Core Facility (OMCF) and its associated bioinformatics group, BioinfOSU, provide facilities, consultation, education and training. Their facilities include modern instruments for the preparation of microarrays of oligo- and polynucleotides, for their hybridization to labeled target nucleic acids, for scanning the fluorescent intensities of spots after hybridization and for computational analysis of the results. Staff includes a Ph. D. level microarray specialist with extensive bioinformatics experience, an applications programmer versed in microarray data handling and a systems administrator. To demonstrate that such staff and facilities stimulate and facilitate research in functional genomics, OMCF and BioinfOSU provide workshops and consultation services to investigators of all levels, as well as making their resources generally available. Groups led by more than 25 Principal Investigators use OSU microarray and bioinformatics facilities to study a diverse range of organisms: Amblyomma americanum (lone star tick), Campylobacter jejuni, Cynodon dactylon (bermuda grass), Emericella nidulans, Gossypium hirsutum (cotton), Influenza viruses, Lycopersicon esculentum (tomato), Rattus norvegicus (rat), Sorghum, Synechocystis sp. PCC6803, Triticum aestivum (bread wheat), and various pathogenic microbes. The work supported by the facility has led to publications in peer-reivewed journals (see section G). In addition to training graduate and postdoctoral students, the scientists leading these laboratories annually welcome numerous undergraduate students into their laboratories to participate in the research. Feedback from clients continually improves the facilities? abilities to provide services and advice.